Journal article
Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model
DD McLeod, DJ Beard, MW Parsons, CR Levi, MB Calford, NJ Spratt
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
Intraluminal occlusion of the middle cerebral artery (MCAo) in rodents is perhaps the most widely used model of stroke, however variability of infarct volume and the ramifications of this on sample sizes remains a problem, particularly for preclinical testing of potential therapeutics. Our data and that of others, has shown a dichotomous distribution of infarct volumes for which there had previously been no clear explanation. When studying perfusion computed tomography cerebral blood volume (CBV) maps obtained during intraluminal MCAo in rats, we observed inadvertent occlusion of the anterior choroidal artery (AChAo) in a subset of animals. We hypothesized that the combined occlusion of the ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC, Australia), Program Grant, #454417 (www.nhmrc.gov.au); the National Stroke Foundation (Australia), Small Project Grant (http://strokefoundation.com.au/research/research-grants-2008-09/); the Hunter Medical Research Institute Stroke Research Project Grant (Grant #G0189810) (www.newcastle.edu.au); and from funds donated by the Greater Building Society (http://www.greater.com.au). N. Spratt received a NHMRC training fellowship, #455632 (www.nhmrc.gov.au). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.